Title of article
Synthesis of novel 5-substituted pyrazole derivatives as cannabinoid antagonists
Author/Authors
Alekseeva، نويسنده , , Olga O. and Mahadevan، نويسنده , , Anu and Wiley، نويسنده , , Jenny L. and Martin، نويسنده , , Billy R. and Razdan، نويسنده , , Raj K.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2005
Pages
3
From page
2159
To page
2161
Abstract
A facile seven-step sequence was developed from 4′-bromopropiophenone, utilizing a Suzuki-type coupling with an alkene, to give several novel 5-substituted pyrazole derivatives in overall yields of 11–31%. They are potent CB1 antagonists and have binding affinities similar to SR 141716A. Like SR 141716A, they may prove to be clinically useful for the treatment of obesity.
Keywords
Cannabinoid receptors , Antagonists , Synthesis , Substituted pyrazoles
Journal title
Tetrahedron Letters
Serial Year
2005
Journal title
Tetrahedron Letters
Record number
1845188
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