Title of article
Traceless solid-phase synthesis of 2-amino-5-alkylidene-thiazol-4-ones
Author/Authors
Maurizio Pulici، نويسنده , , Maurizio and Quartieri، نويسنده , , Francesca، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2005
Pages
5
From page
2387
To page
2391
Abstract
2-Amino-5-alkylidene-thiazol-4-ones bearing two diversity points are prepared by a solid-phase strategy exploiting rhodanine as the starting material. Rhodanine is first loaded on bromo-Wang resin, subjected to Knovenagel condensation with aldehydes, and cleaved off the resin in a traceless manner by means of an amine.
Keywords
solid-phase synthesis , traceless linker , thiazolone , Knovenagel reaction
Journal title
Tetrahedron Letters
Serial Year
2005
Journal title
Tetrahedron Letters
Record number
1845271
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