Title of article
Synthesis of PI-88 analogue using novel O-glycosidation of exo-methylenesugars
Author/Authors
Rie Namme، نويسنده , , Rie and Mitsugi، نويسنده , , Takashi and Takahashi، نويسنده , , Hideyo and Ikegami، نويسنده , , Shiro، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2005
Pages
4
From page
3033
To page
3036
Abstract
Acid-promoted α-stereoselective O-glycosidation of 1-exo-methylenesugars was successfully applied to the synthesis of a PI-88 analogue. By using methanesulfonic acid as a promoter, 1′-C-methyl-α-disaccharides with p-methoxybenzyl protection were obtained in high yield. The sequence of selective deprotection and glycosidation provided 1-C-methyl-pentasaccharide efficiently.
Keywords
1-exo-Methylenesugar , O-glycosidation , PI-88 , Heparanase inhibitor
Journal title
Tetrahedron Letters
Serial Year
2005
Journal title
Tetrahedron Letters
Record number
1845491
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