Title of article
Selective 1,2-syn alkynylation of an open chain sugar: the prominent role of zinc chloride addition
Author/Authors
Guillarme، نويسنده , , Stéphane and Haudrechy، نويسنده , , Arnaud، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2005
Pages
4
From page
3175
To page
3178
Abstract
Depending on the metal, solvent and protective groups, functionalized aldehydes may react through either Felkin or chelated transition states leading to the Felkin–Anh product or the 1,2-anti Felkin–Anh product, respectively. Zinc chloride addition proved to be a key aspect in order to favor 1,2-syn nucleophilic attack.
Keywords
1 , Zinc chelation , 2-Dialkoxyaldehydes , Alkynylation
Journal title
Tetrahedron Letters
Serial Year
2005
Journal title
Tetrahedron Letters
Record number
1845540
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