Author/Authors :
Song، نويسنده , , Chun and Ma، نويسنده , , Changqin and Ma، نويسنده , , Yudao and Feng، نويسنده , , Wenhua and Ma، نويسنده , , Shutao and Chai، نويسنده , , Qiang and Andrus، نويسنده , , Merritt B.، نويسنده ,
Abstract :
New chiral bis-paracyclophane N-heterocyclic carbene (NHC) ligands 1–3 have been explored for ruthenium catalyzed asymmetric hydrosilylation of ketones using diphenylsilane to give enantioenriched alcohols. These ligands provide for efficient asymmetric reduction in the presence of silver(I) triflate (1 mol %) at room temperature with high reactivity and selectivity. Acetophenone 4 was reduced with 1 mol % catalyst in 96% isolated yield, 97% ee. Following removal of the silyl ether, various alcohols 5 were obtained from aromatic ketones in high yield and selectivity.
