Title of article :
Sustainable domino Michael reaction catalyzed by a Brّnsted base on silica gel: synthesis of bicyclo[2.2.2]octane-2,5-dione derivatives
Author/Authors :
Fukushima، نويسنده , , Masakazu and Endou، نويسنده , , Satoru and Hoshi، نويسنده , , Takashi and Suzuki، نويسنده , , Toshio and Hagiwara، نويسنده , , Hisahiro، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2005
Abstract :
Domino Michael reactions of oxophorone and its derivatives 4 with Michael partners 3 have been effected to give bicyclo[2.2.2]octane-2,5-dione derivatives 7 by a catalytic amount of a Brّnsted base (NMAP-Li) generated from N-methylaminopropylated silica gel (NMAP) and n-BuLi. The NMAP pellets were efficiently reused up to six times in 86% average yield.
Keywords :
Heterogeneous base , Silica gel anion , Domino reaction , Michael reaction
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
