Supercritical CO2 improved phosphine imide reaction on peracetylated β-cyclodextrin

Supercritical CO2 (sCO2) was successfully used as solvent and reagent in the ‘one-pot’ phosphine imide reaction. In sCO2 smooth conditions and with or without assistance of triphenylphosphine-bounded polymer, the reaction efficiently leads to the desired urea β-Cd compounds in a short time, bringing an interesting alternative for solving problems of OVC and hazardous reagent substitution in the synthesis of ureido-Cds and, by extension, of urea derivatives.