Author/Authors :
Edo، نويسنده , , Naoki and Miyai، نويسنده , , Kosuke and Ogata، نويسنده , , Sho and Nakanishi، نويسنده , , Kuniaki and Hiroi، نويسنده , , Sadayuki and Tominaga، نويسنده , , Susumu and Aiko، نويسنده , , Satoshi and Kawai-Nakamura، نويسنده , , Toshiaki، نويسنده ,
Abstract :
Thromboangiitis obliterans (TAO, Buergerʹs disease) is an idiopathic, recurrent, segmental, nonatherosclerotic, inflammatory, occlusive vascular disease with a poorly understood pathogenesis. Intestinal or multi-organ involvement is rare. Recent immunohistochemical analyses of ordinary TAO have indicated an inflammatory and immunologic pathogenesis. We report a case of TAO involving multiple large vessels. By immunohistochemistry, CD3(+) T cells were revealed around the recanalization sites within the abdominal aorta. CD4(+) T cells were almost equal in number to CD8(+) T cells. These findings indicate the participation of inflammatory and immunologic processes in TAO with multi-organ involvement (as in ordinary TAO).
