An efficient construction of a C3-symmetric macrocycle by head to tail cyclotrimerization of an unsymmetrical diene via a sequence of highly regio- and stereoselective metathesis reactions

A sequence of highly regio- and stereoselective intermolecular metatheses followed by ring-closing metathesis of an 1-allyl-3-(3-butenyl)cyclohexanol led to a C3-symmetric head to tail cyclic trimer; a 24-membered macrocycle containing three inward directed hydroxyl groups creating a hydrophilic cavity.