Title of article
Double nucleophilic addition of bis(trimethylsilyl)ketene acetals to carbon–carbon double bonds of pyrazines: formation of polycyclic γ-lactones
Author/Authors
Rudler، نويسنده , , Henri and Denise، نويسنده , , Bernard and Xu، نويسنده , , Yiming and Vaissermann، نويسنده , , Jacqueline، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2005
Pages
3
From page
3449
To page
3451
Abstract
The double activation of pyrazines upon their interaction with methyl chloroformate leading in the presence of bis(TMS)ketene acetals to polycyclic N-containing γ-lactones parallels the interaction of the same ketene acetals with metal-activated aromatics. The fundamental role of the two oxygen–silicon bonds is outlined. This result broadens the scope of application of these ketene acetals as potential 1,3-dinucleophiles.
Keywords
ketene acetals , Pyrazines , Lactones
Journal title
Tetrahedron Letters
Serial Year
2005
Journal title
Tetrahedron Letters
Record number
1845635
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