Author/Authors :
Zhu، نويسنده , , Juliang and Wong، نويسنده , , Henry and Zhang، نويسنده , , Zhongxing and Yin، نويسنده , , Zhiwei and Kadow، نويسنده , , John F. and Meanwell، نويسنده , , Nicholas A. and Wang، نويسنده , , Tao، نويسنده ,
Abstract :
The SNAr-type reaction of the piperidine amide of cyanoacetic acid with a series of heteroaryl halides followed by in situ oxidation of the resultant anion with peracetic acid provided a convenient, one-pot protocol for preparative access to heteroaryl α-keto amides. In this procedure, the amide of cyanoacetic acid functions as an Umpolung-type synthon of the α-keto amide moiety.
Keywords :
Acyl carbanion equivalent , Condensation–oxidation , ?-Cyano acetamide , Heteroaryl ?-keto amide
