Title of article
TiCl(OiPr)3 and NaBH(OAc)3: an efficient reagent combination for the reductive amination of aldehydes by electron-deficient amines
Author/Authors
Gutierrez، نويسنده , , Corey D. and Bavetsias، نويسنده , , Vassilios and McDonald، نويسنده , , Edward، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2005
Pages
3
From page
3595
To page
3597
Abstract
Sodium triacetoxyborohydride, NaBH(OAc)3 with tri-isopropoxytitanium chloride, TiCl(OiPr)3 is a useful reagent combination for reductive amination. Electron-deficient amines and heteroaromatic amines such as 2-aminopyrimidine and 2-aminothiazole can be reductively alkylated at room temperature to afford the corresponding secondary amines in good yields.
Journal title
Tetrahedron Letters
Serial Year
2005
Journal title
Tetrahedron Letters
Record number
1845701
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