Title of article
First total synthesis of 7(S),17(S)-Resolvin D5, a potent anti-inflammatory docosanoid
Author/Authors
Rodrيguez، نويسنده , , Ana R. and Spur، نويسنده , , Bernd W.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2005
Pages
5
From page
3623
To page
3627
Abstract
The first total synthesis of 7(S),17(S)-Resolvin D5, a lipid mediator derived from docosahexaenoic acid, has been achieved. The chiral centers were generated via a Co-salen hydrolytic kinetic resolution of a terminal epoxide with >99% ee. Key steps include Takai olefination, Pd0/CuI coupling and simultaneous deprotection and ester cleavage with lipase from Candida rugosa.
Keywords
Resolvins , Hydrolytic kinetic resolution , palladium catalyst , Takai reaction , Lindlar reduction
Journal title
Tetrahedron Letters
Serial Year
2005
Journal title
Tetrahedron Letters
Record number
1845707
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