Title of article
Acceleration of the Passerini reaction in the presence of nucleophilic additives
Author/Authors
Mironov، نويسنده , , Maxim A. and Ivantsova، نويسنده , , Maria N. and Tokareva، نويسنده , , Maria I. and Mokrushin، نويسنده , , Vladimir S.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2005
Pages
4
From page
3957
To page
3960
Abstract
An accelerating effect of nucleophilic additives was revealed for the Passerini multi-component reaction. The influence of aqueous solutions on the reaction rate was studied in detail and the direct involvement of water in the bond-making step was attributed as the basis of an accelerating effect. Other nucleophiles were tested as alternatives to water; as a result N-hydroxysuccinimide is proposed as an accelerant of the Passerini reaction.
Keywords
Nucleophilic additives , Catalysis , Isocyanides , Passerini reaction , Aqueous solutions
Journal title
Tetrahedron Letters
Serial Year
2005
Journal title
Tetrahedron Letters
Record number
1845841
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