Title of article
New methodology for 2-alkylation of 3-furoic acids: application to the synthesis of tethered UC-781/d4T bifunctional HIV reverse-transcriptase inhibitors
Author/Authors
Arnott، نويسنده , , Gareth and Hunter، نويسنده , , Roger and Mbeki، نويسنده , , Linda and Mohamed، نويسنده , , Ebrahim، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2005
Pages
4
From page
4023
To page
4026
Abstract
New methodology for 2-alkylation of 3-furoic acids is presented involving Wittig reactions of the 3-methoxycarbonyl-2-furanylmethylphosphonium salt. The methodology has been used to prepare a tethered 2-alkylated-UC-781/d4T conjugate as a potentially new type of HIV reverse-transcriptase inhibitor.
Keywords
Bifunctional HIV reverse-transcriptase inhibitors , Furan alkylation , Wittig reaction of 2-furanylphosphonium salt , Alkylated-UC-781
Journal title
Tetrahedron Letters
Serial Year
2005
Journal title
Tetrahedron Letters
Record number
1845869
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