Author/Authors :
Yin، نويسنده , , Zhiwei and Zhang، نويسنده , , Zhongxing and Zhu، نويسنده , , Juliang and Wong، نويسنده , , Henry and Kadow، نويسنده , , John F. and Meanwell، نويسنده , , Nicholas A. and Wang، نويسنده , , Tao، نويسنده ,
Abstract :
Aryl aminoacetonitriles are oxidized by NiO2–H2O or MnO2 in the presence of a wide range of NH2-containing compounds to afford aryl amidines, presumably via iminium intermediates. A ‘one-pot’ procedure for the preparation of heteroaryl amidines from N-containing heteroaryl halides through a process comprising sequential SNAr substitution and oxidation has also been developed.
Keywords :
manganese oxide , Condensation–oxidation , Aminoacetonitrile , Nickel peroxide , Heteroaryl amidine , Aryl amidine
