Author/Authors :
Han، نويسنده , , Quanbin and Lu، نويسنده , , Yang and Wu، نويسنده , , Li and He، نويسنده , , Zhen-Dan and Qiao، نويسنده , , Chun-Feng and Xu، نويسنده , , Hong-Xi and Zheng، نويسنده , , Qitai and Sun، نويسنده , , Han-Dong، نويسنده ,
Abstract :
A novel asymmetric ent-kauranoid dimer, lushanrubescensin J (1), was isolated from Isodon rubescens var. lushanensis. Its structure was elucidated by the spectroscopic evidences. The stereochemistry was confirmed by the single crystal X-ray diffraction of its tetraacetate. Compound (1) exhibited potent inhibitory activity against K562 cells with IC50 = 0.93 μg/mL.
Keywords :
Isodon rubescens var. lushanensis , ent-Kaurane dimer , Lushanrubescensin J , Tetraacetate
