Author/Authors :
Boris Lastdrager، نويسنده , , Bas and Timmer، نويسنده , , Mattie S.M. and van der Marel، نويسنده , , Gijsbert A. and Overkleeft، نويسنده , , Herman S.، نويسنده ,
Abstract :
A convenient method for the synthesis of functionalised 1,7-dioxaspiro[5.5]undecanes using acid-catalysed spiroketalisations of substituted dihydroxyketones is described. The dihydroxyketones were readily prepared from appropriately substituted hydroxy esters via Claisen self-condensation followed by decarboxylation.
