Weak C–H⋯O hydrogen bonds between diacylamidopyridine and thymine derivatives in solution and its influence on the binding constants

The presence of C–H⋯O hydrogen bonds in a complex composed of 2-(acrylamido)-6-(methylamido) pyridine and 1-octyl thymine is demonstrated by 1H, 13C NMR study and X-ray analysis. Further titration experiment shows these weak C–H⋯O hydrogen bonds will affect the binding constants through a geometric effect compared with other structural analogous systems.