Title of article
A cyclopropanol approach to the synthesis of the C13–C21 fragment of epothilones from diethyl (S)-malate
Author/Authors
Bekish، نويسنده , , Andrei V. and Isakov، نويسنده , , Vladimir E. and Kulinkovich، نويسنده , , Oleg G.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2005
Pages
3
From page
6979
To page
6981
Abstract
A convenient new approach to the synthesis of the C13–C21 epothilone fragment using the cyclopropanation of the ethoxycarbonyl groups in O-THP protected diethyl (S)-malate with ethylmagnesium bromide in the presence of titanium(IV) isopropoxide followed by site-selective cyclopropane cleavage as the key steps has been performed.
Keywords
allyl halides , Epothilones , cyclopropanols , (S)-Malic acid
Journal title
Tetrahedron Letters
Serial Year
2005
Journal title
Tetrahedron Letters
Record number
1846842
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