Title of article
Design and synthesis of a potent biotinylated Smac mimetic
Author/Authors
Sun، نويسنده , , Haiying and Nikolovska-Coleska، نويسنده , , Zaneta and Yang، نويسنده , , Chao-Yie and Wang، نويسنده , , Shaomeng، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2005
Pages
4
From page
7015
To page
7018
Abstract
A biotinylated Smac mimetic (2) was designed based upon our previously reported potent, conformationally constrained Smac mimetic (1). Smac mimetic (2) was synthesized and determined to bind to XIAP protein with a high-affinity (Ki value of 13 nM) and is therefore a useful pharmacological tool for probing the intracellular targets of this class of potent Smac mimetics.
Keywords
Biotinylated ligand , XIAP , Smac mimetic
Journal title
Tetrahedron Letters
Serial Year
2005
Journal title
Tetrahedron Letters
Record number
1846855
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