Synthesis of Fmoc-protected aza-β3-amino acids via reductive amination of glyoxylic acid

The reductive amination of glyoxylic acid, with a protected Fmoc hydrazine, has been developed as a simple and efficient method for the preparation of Fmoc-aza-β3-amino acid residues (aza-β3-aa). Anchoring on resin of these residues will be described as well as the synthesis of hybrid peptide.