Title of article :
Barbier allylation–Prins reaction of PEG-bound aldehydes—soluble polymer-supported synthesis of 2,4,6-trisubstituted tetrahydropyrans
Author/Authors :
Sampath Kumar، نويسنده , , H.M. and Qazi، نويسنده , , Naveed Ahmed and Shafi، نويسنده , , Syed and Naveen Kumar، نويسنده , , V. and Krishna، نويسنده , , A.D. and Yadav، نويسنده , , J.S.، نويسنده ,
Abstract :
PEG-bound aldehydes undergo zinc-mediated Barbier allylation to form homoallylic alcohols, which on further reaction with various aldehydes in the presence of BF3·Et2O through a Prins cyclization afford 4-hydroxytetrahydropyrans and 4-fluorotetrahydropyrans.
Keywords :
PEG , Prins cyclization , Barbier allylation , tetrahydropyran
