Title of article :
An efficient synthesis of LY544344·HCl: a prodrug of mGluR2 agonist LY354740
Author/Authors :
Coffey، نويسنده , , D. Scott and Hawk، نويسنده , , Mai Khanh and Pedersen، نويسنده , , Steven W. and Vaid، نويسنده , , Radhe K.، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2005
Pages :
4
From page :
7299
To page :
7302
Abstract :
LY544344·HCl was efficiently prepared in two steps from LY354740. The key step highlighted the in situ masking of the carboxylic acid groups as trimethylsilyl esters to facilitate an effective acylation reaction.
Keywords :
metabotropic glutamate receptors , Prodrugs , Trimethylsilyl esters , peptide coupling
Journal title :
Tetrahedron Letters
Serial Year :
2005
Journal title :
Tetrahedron Letters
Record number :
1846983
Link To Document :
https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=1846983
بازگشت