Title of article
An efficient synthesis of LY544344·HCl: a prodrug of mGluR2 agonist LY354740
Author/Authors
Coffey، نويسنده , , D. Scott and Hawk، نويسنده , , Mai Khanh and Pedersen، نويسنده , , Steven W. and Vaid، نويسنده , , Radhe K.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2005
Pages
4
From page
7299
To page
7302
Abstract
LY544344·HCl was efficiently prepared in two steps from LY354740. The key step highlighted the in situ masking of the carboxylic acid groups as trimethylsilyl esters to facilitate an effective acylation reaction.
Keywords
metabotropic glutamate receptors , Prodrugs , Trimethylsilyl esters , peptide coupling
Journal title
Tetrahedron Letters
Serial Year
2005
Journal title
Tetrahedron Letters
Record number
1846983
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