Author/Authors :
Xi، نويسنده , , Ning and Xu، نويسنده , , Shimin and Cheng، نويسنده , , Yuan and Tasker، نويسنده , , Andrew S. and Hungate، نويسنده , , Randall W. and Reider، نويسنده , , Paul J.، نويسنده ,
Abstract :
A regio-specific synthesis of N-substituted imidazoles is described. Readily available α-amino acids are converted to α-aminocarbonyl derivatives and reacted with various isothiocyanates to give N-substituted cyclic thioureas. Oxidative or reductive desulfurization of the cyclic thioureas affords structurally diversified imidazoles in good to excellent yields.
Keywords :
Regio-controlled synthesis , amino acids , Cyclic thioureas , imidazoles
