Title of article
Regio-controlled synthesis of N-substituted imidazoles
Author/Authors
Xi، نويسنده , , Ning and Xu، نويسنده , , Shimin and Cheng، نويسنده , , Yuan and Tasker، نويسنده , , Andrew S. and Hungate، نويسنده , , Randall W. and Reider، نويسنده , , Paul J.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2005
Pages
5
From page
7315
To page
7319
Abstract
A regio-specific synthesis of N-substituted imidazoles is described. Readily available α-amino acids are converted to α-aminocarbonyl derivatives and reacted with various isothiocyanates to give N-substituted cyclic thioureas. Oxidative or reductive desulfurization of the cyclic thioureas affords structurally diversified imidazoles in good to excellent yields.
Keywords
Regio-controlled synthesis , amino acids , Cyclic thioureas , imidazoles
Journal title
Tetrahedron Letters
Serial Year
2005
Journal title
Tetrahedron Letters
Record number
1846990
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