Title of article
Synthesis of a cell-permeable analogue of a glycosylphosphatidylinositol (GPI) intermediate that is toxic to the living bloodstream form of Trypanosoma brucei
Author/Authors
Arthur Crossman Jr.، نويسنده , , Arthur and Smith، نويسنده , , Terry K. and Ferguson، نويسنده , , Michael A.J and Brimacombe، نويسنده , , John S.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2005
Pages
3
From page
7419
To page
7421
Abstract
The synthesis of two cell-permeable analogues related to a GPI intermediate is described for studies with living trypanosomes and human (HeLa) cells. One of the analogues is metabolised by the former GPI pathway and is toxic to the parasite Trypanosoma brucei but not to human cells.
Keywords
Trypanosoma brucei , Cell-permeable glycosylphosphatidylinositol (GPI) analogues , African sleeping sickness , Bioactivatable acetoxymethyl ester
Journal title
Tetrahedron Letters
Serial Year
2005
Journal title
Tetrahedron Letters
Record number
1847040
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