Title of article
Synthesis of 5-aza-analogues of angucyclines: manipulation of the 2-deoxy-C-glycoside subunit
Author/Authors
Vu، نويسنده , , Nguyen Quang and Dujardin، نويسنده , , Gilles and Collet، نويسنده , , Sylvain C. and Raiber، نويسنده , , Eun-Ang and Guingant، نويسنده , , André Y. and Evain، نويسنده , , Michel، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2005
Pages
5
From page
7669
To page
7673
Abstract
Based on a heterocyclic Diels–Alder strategy, a concise synthesis of 5-aza-analogues of angucyclines bearing a 2-deoxy-C-glycoside subunit is reported. Starting from a common intermediate, a peracetylated D-2-deoxyglucose could be linked to carbons C9 or C10 of the tetracyclic framework. Further manipulations of the sugar residue allowed the installation of bromo and azido substituents at carbon C6′.
Keywords
angucycline , Angucyclinone , Angucycline-5-aza-analogue , 2-Aza-1 , 3-diene , 2-Bromo-naphtoquinone , Hetero-Diels–Alder reaction , C-glycoside
Journal title
Tetrahedron Letters
Serial Year
2005
Journal title
Tetrahedron Letters
Record number
1847167
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