Title of article
Restricted expression of tumor necrosis factor-related apoptosis-inducing ligand receptor 4 in human peripheral blood lymphocytes
Author/Authors
Hasegawa، نويسنده , , Hiroo and Yamada، نويسنده , , Yasuaki and Harasawa، نويسنده , , Hitomi and Tsuji، نويسنده , , Tomohiro and Murata، نويسنده , , Ken and Sugahara، نويسنده , , Kazuyuki and Tsuruda، نويسنده , , Kazuto and Masuda، نويسنده , , Masato and Takasu، نويسنده , , Nobuyuki and Kamihira، نويسنده , , Shimeru Kamihira، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
7
From page
1
To page
7
Abstract
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces apoptosis in tumor but not normal cells, thus providing therapeutic possibilities for human cancers. However, it is not fully clear how widespread TRAIL receptors are, or how TRAIL signaling is modulated in normal cells. We characterized cell surface expression of TRAIL receptors in normal healthy donor peripheral blood and report that each of the TRAIL receptors are characteristically expressed on restricted cell populations. TRAIL-R1 is distinctively expressed on B-lymphocytes, TRAIL-R2 on monocytes, TRAIL-R3 on neutrophils and most impressively, CD8+ lymphocytes and NKT lymphocytes but not CD4+ lymphocytes express TRAIL-R4.
Keywords
TRAIL receptor , Decoy receptor , TRAIL-R4 , NKT lymphocytes , CD8+ lymphocytes
Journal title
Cellular Immunology
Serial Year
2004
Journal title
Cellular Immunology
Record number
1847227
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