Title of article
Selective displacement of aryl fluorides with hydroquinone: synthesis of 4-phenoxyphenols
Author/Authors
Marcune، نويسنده , , Benjamin F. and Hillier، نويسنده , , Michael C. and Marcoux، نويسنده , , Jean-François and Humphrey، نويسنده , , Guy R.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2005
Pages
4
From page
7823
To page
7826
Abstract
The selective displacement of a variety of aryl fluorides with hydroquinone has been achieved to give substituted 4-phenoxyphenols 3. In some cases the addition of 18-crown-6 resulted in a significant rate enhancement, and the reactions could be carried out at lower temperature. One of these derivatives, 3a (X = Cl) was converted to 2-propyl-4-(4-chlorophenoxy)phenol 2a, a precursor to the PPARγ receptor agonist 1.
Keywords
hydroquinone , Aryl fluorides , Fluoride displacement
Journal title
Tetrahedron Letters
Serial Year
2005
Journal title
Tetrahedron Letters
Record number
1847257
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