Title of article
Preparation of RCM substrates for azepinoindole synthesis: reductive amination versus tetrahydro-γ-carboline formation
Author/Authors
Bennasar، نويسنده , , M.-Lluïsa and Zulaica، نويسنده , , Ester and Alonso، نويسنده , , Sandra، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2005
Pages
4
From page
7881
To page
7884
Abstract
Treatment of N-(phenylsulfonyl)-2-vinyl-3-indolecarbaldehydes with primary aliphatic amines under mild reductive amination conditions leads to tetrahydro-γ-carbolines in high yield. The process can be suppressed by changing the protecting group at the indole nitrogen for a methoxymethyl group, thus allowing the preparation of RCM substrates for azepinoindole synthesis.
Keywords
reductive amination , Tetrahydro-?-carbolines , ring-closing metathesis , Azepinoindoles
Journal title
Tetrahedron Letters
Serial Year
2005
Journal title
Tetrahedron Letters
Record number
1847300
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