Author/Authors :
HETTA، M نويسنده Pharmacognosy Department, Faculty of Pharmacy, Beni Suef Univ., Egypt 2Botany Department, Faculty of Science, Beni Suef Univ., Egypt HETTA, M , HASSAN، S نويسنده Botany Department, Faculty of Science, Beni Suef Univ., Egypt HASSAN, S , ABDEL-TAWAB، S نويسنده Zoology Department, Faculty of Science, Beni Suef Univ., Egypt ABDEL-TAWAB, S , BASTAWY، M نويسنده Chemistry Department, Faculty of Science, Beni Suef Univ., Egypt BASTAWY, M , MAHMOUD، B نويسنده Biochemistry Department, Faculty of Science, Beni Suef Univ., Egypt MAHMOUD, B
Abstract :
The polysaccharides of Acanthophora spicifera and Cystoseira trinode were isolated and their
components identified using different chemical and spectral techniques. Their effects were evaluated for the
first time on hyperlipidemic rats. Atorvastatin Ca (Lipitor®) was used as a reference drug. Results revealed
that the polysaccharides isolated were of sulfate type. Acanthophora spicifera lowered the level of total serum
lipids, total cholesterol (TC), triglycerides (TG) and low-density lipoproteins (LDL-C) by 48%, 49.6%, 63%
and 80.6% respectively. High-density lipoproteins (HDL-C) level was elevated by 1.14 fold. For Cystoseira
trinode total lipids, TC, TG and LDL-C were decreased by 25.5%, 49%, 51% and 91% respectively. The level
of HDL-C was elevated by 1.5 fold in comparison with the hyperlipidemic rats. The histopathological results
proved the ameliorated effect after using the isolated polysaccharides of both algae. Alanine aminotransferase
(ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) activities were decreased in
hypercholesterolemic groups by values of 63%, 34% and 45%, respectively when treated with A. spicifera
extract. The treatment with C. trinode extract and Atorvastatin exhibited a noticeable amelioration in activity
with hypercholesterolemic groups as compared to their corresponding controls.
