Title of article
Practical synthesis of (2S,3R)-3-hydroxy-3-methylproline, a constituent of papuamides, using a diastereoselective tandem Michael-aldol reaction
Author/Authors
Makino، نويسنده , , Kazuishi and Nagata، نويسنده , , Eri and Hamada، نويسنده , , Yasumasa، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2005
Pages
4
From page
8159
To page
8162
Abstract
(2S,3R)-3-Hydroxy-3-methylproline, a constituent of cyclodepsipeptides polyoxypeptins A and B, was efficiently synthesized by lithium chloride-induced diastereoselective tandem Michael-aldol reaction using methyl vinyl ketone and N-1-naphthylsulfonylglycine (R)-binaphthyl ester and subsequent hydrolysis of the product in 39% overall yield and five steps.
Keywords
Glycine (R)-binaphthyl ester , 3R)-3-hydroxy-3-methylproline , tandem Michael-aldol reaction , (2S , Polyoxypeptin A , Methyl vinyl ketone
Journal title
Tetrahedron Letters
Serial Year
2005
Journal title
Tetrahedron Letters
Record number
1847488
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