Title of article
Enantioselective synthesis of β-amino-diacids
Author/Authors
Alladoum، نويسنده , , Jeanne and Dechoux، نويسنده , , Luc، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2005
Pages
3
From page
8203
To page
8205
Abstract
An efficient route to orthogonally protected β-amino-diacids is described: chiral derivative 3 was shown to be a precursor of enantiopure substituted β-amino acids. The key step of the procedure is a diastereoselective reduction of β-enaminolactones 5 by NaBH3CN in CH2Cl2. A study concerning the regio- and diastereoselectivity of alkylation of β-enaminolactone 3 is also presented.
Keywords
?-Amino acids , (R)-Phenylglycinol , ?-Amino-diacids , ?-Enaminolactone , asymmetric synthesis
Journal title
Tetrahedron Letters
Serial Year
2005
Journal title
Tetrahedron Letters
Record number
1847683
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