A correlation study of bisphosphine ligand bite angles with enantioselectivity in Pd-catalyzed asymmetric transformations

Among the bisphosphine ligands, we have previously developed Cn-TunePhos (n = 1–6) as a family of ligands with tunable bite angles. The increase in spacer –CH2– groups in this family of ligands causes changes in ligand dihedral angle, which in turn causes P–Pd–P bite angle variation. Pd-catalyzed asymmetric alkylations and cycloadditions have been tested with Cn-TunePhos ligands. This study aims at a possible correlation between ligand bite angles with enantioselectivity of the Pd-catalyzed asymmetric products.