Title of article
Meyers’ bicyclic lactam formation under mild and highly stereoselective conditions
Author/Authors
Penhoat، نويسنده , , Maël and Leleu، نويسنده , , Stephane and Dupas، نويسنده , , Georges and Papamicaël، نويسنده , , Cyril and Marsais، نويسنده , , Francis and Levacher، نويسنده , , Vincent، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2005
Pages
5
From page
8385
To page
8389
Abstract
New and mild conditions to prepare chiral bicyclic lactams in high yields and high diastereoselectivities are reported herein. This approach based on the activation of the carboxylic acid by means of Mukaiyama’s reagent is an excellent alternative to Meyers’ dehydrating conditions and provide the main advantage to work at lower temperature (40 °C). Higher diastereoselectivity was obtained with 5,7-bicyclic lactams (de = 82% instead of 44% under standard dehydrating conditions).
Keywords
Meyers’ bicyclic lactam , thioester , Mukaiyama’s reagent , (R)-Phenylglycinol
Journal title
Tetrahedron Letters
Serial Year
2005
Journal title
Tetrahedron Letters
Record number
1847746
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