Author/Authors :
Junge، نويسنده , , Kristin M. and Hِrnig، نويسنده , , Friederike and Herberth، نويسنده , , Gunda and Rِder، نويسنده , , Stefan and Kohajda، نويسنده , , Tibor and Rolle-Kampczyk، نويسنده , , Ulrike and von Bergen، نويسنده , , Martin and Borte، نويسنده , , Michael and Simon، نويسنده , , Jan-Christoph and Heroux، نويسنده , , Delia and Denburg، نويسنده , , Judah A. and Lehmann، نويسنده , , Irina، نويسنده ,
Abstract :
AbstractRationale
lood eosinophil/basophil progenitor cells (Eo/B) of high risk infants have been shown to predict respiratory illnesses in infancy. Here we investigated this association in a population-based cohort. Furthermore, we analysed whether newborns Th1/Th2 balance and prenatal environmental exposure impact Eo/B recruitment.
s
ub-cohort of the LINA study cord blood mononuclear cells were used for methylcellulose assays to assess Eo/B differentiation. Questionnaires were recorded during pregnancy and annually thereafter. Volatile organic compounds were measured during pregnancy and cord blood cytokines after ex vivo stimulation.
s
lood IL-4 and IL-13 positively correlated with Eo/B. Tobacco smoke related benzene was also positively associated with Eo/B. Enhanced Eo/B numbers increased the risk for wheezing within the first 24 months.
sions
sociation between cord blood Eo/B and respiratory illnesses is not restricted to high-risk children. Prenatal environmental exposure and a Th2 milieu at birth contribute to Eo/B recruitment.
Keywords :
LinA , Two year old children , cord blood , Eosinophil/basophil progenitors , Wheezing , Bronchitis
