Author/Authors :
Ohno، نويسنده , , Takamasa and Nagatsu، نويسنده , , Akito and Nakagawa، نويسنده , , Munehiro and Inoue، نويسنده , , Makoto and Li، نويسنده , , Yun-Mo and Minatoguchi، نويسنده , , Shinya and Mizukami، نويسنده , , Hajime and Fujiwara، نويسنده , , Hisayoshi، نويسنده ,
Abstract :
In the present study, new sesquiterpene lactones (1) and (2) were isolated from the EtOAc soluble fraction of the water extract of Linderae Radix through bioassay-guided fractionation and isolation methods. The structure of these compounds was elucidated by spectroscopic analysis of their 2D NMR spectra, including COSY, HMBC, and HMQC techniques. Two isolates showed significant cytotoxicity against the human small cell lung cancer cell SBC-3, and lesser cytotoxicity against mouse fibroblast cell 3T3-L1.
Keywords :
Antitumor activity , Lindera strychnifolia , Sesquiterpene lactone , Lauraceae
