Author/Authors :
Pelotier، نويسنده , , Béatrice and Priem، نويسنده , , Ghislaine and Macdonald، نويسنده , , Simon J.F. and Anson، نويسنده , , Mike S. and Upton، نويسنده , , Richard J. and Campbell، نويسنده , , Ian B.، نويسنده ,
Abstract :
A variety of easily removable protecting groups were tested in the kinetic resolution of N-protected β-aminoalcohols using chiral catalysts derived from N-4′-pyridinyl-α-methyl proline. The trifluoroacetyl group was the most promising protecting group as it gave the highest selectivities with all alcohols tested and can easily be removed without loss of enantiomeric excess. This strategy constitutes a convenient method for the kinetic resolution of β-aminoalcohols.
Keywords :
Trifluoroacetamides , kinetic resolution , ?-Aminoalcohols , Nonenzymatic nucleophilic catalysts , Enantioselective acylations
