Author/Authors :
Li، نويسنده , , Xianfeng and Szardenings، نويسنده , , Anna Katrin and Holmes، نويسنده , , Christopher P. and Wang، نويسنده , , Liang and Bhandari، نويسنده , , Ashok and Shi، نويسنده , , Lihong and Navre، نويسنده , , Marc and Jang، نويسنده , , Larry and Grove، نويسنده , , J. Russell، نويسنده ,
Abstract :
A new method for the synthesis of functionalized biaryl α-ketophosphonic acids has been developed. The key step involves the use of sodium bromobenzoyl phosphonates to react with polymer-bound boronic acids via microwave-assisted aqueous Suzuki coupling. This approach provides rapid access to a wide range of diverse biaryl analogues containing an α-ketophosphonic acid moiety.
Keywords :
Biaryl scaffolds , Aqueous Suzuki coupling , PTP inhibitors , ?-Ketophosphonic acids
