Author/Authors :
Belley، نويسنده , , Michel and Sauer، نويسنده , , Effiette and Beaudoin، نويسنده , , Daniel and Duspara، نويسنده , , Petar and Trimble، نويسنده , , Laird A. and Dubé، نويسنده , , Pascal، نويسنده ,
Abstract :
Catalytic hydrogenation of (2-nitrophenyl)acetonitriles bearing an electron-withdrawing substituent α to the nitrile, using Pd/C and (Ph3P)4Pd, affords N-hydroxy-2-aminoindoles in good to excellent yields. (Ph3P)4Pd decreases the reduction rate of the intermediate hydroxylamine and acts as a catalyst during the cyclization onto the nitrile.
Keywords :
reductive cyclization , N-Hydroxy-2-aminoindole , Tetrakis(triphenylphosphine)palladium(0) , Catalytic hydrogenation , (Ph3P)4Pd
