Title of article :
Synthesis of 1,2,3-trisubstituted cyclopropanes by MIRC reactions of dithianyllithiums with monocarboxylic vinyl epoxide analogues
Author/Authors :
Tang، نويسنده , , Shouchu and Xie، نويسنده , , Xingang and Huo، نويسنده , , Xing and Liang، نويسنده , , Qiren and She، نويسنده , , Xuegong and Pan، نويسنده , , Xinfu، نويسنده ,
Abstract :
A variety of cyclopropane derivatives bearing stereochemistry at all three positions on the ring were readily obtained in a high yield of 76–92% and high stereoselectivity (trans:cis > 95:5) when the monocarboxylic vinyl epoxide analogues reacted with dithianyllithiums in the presence of HMPA. This reaction was supposed to be a tandem conjugation addition-opening epoxide ring sequence.
Keywords :
1 , 2 , 3-Trisubstituted cyclopropanes , MIRC reactions , vinyl epoxide
