Author/Authors :
Ren، نويسنده , , Yunlai and Tian، نويسنده , , Xinzhe and Sun، نويسنده , , Kunpeng and Xu، نويسنده , , Jian and Xu، نويسنده , , Xianlun and Lu، نويسنده , , Shijie، نويسنده ,
Abstract :
Some readily available chiral diols from indene and d-mannitol were investigated as chiral modifiers in lithium aluminum hydride reduction of ketones, and it was discovered that further modification of these reducing reagents by a simple a-amino alcohol resulted in a remarkable increase in optical yield. Among the investigated chiral modifiers, chiral diol 1 gave the highest enantioselectivities.
Keywords :
asymmetric reduction , Diol , Lithium tetrahydridoaluminate , Ketone
