Author/Authors :
Yang، نويسنده , , Qin and Gao، نويسنده , , Wenzhong and Deng، نويسنده , , Jingen and Zhang، نويسنده , , Xumu Zhang، نويسنده ,
Abstract :
Rh- or Ru-catalyzed highly enantioselective hydrogenation of N-phthaloyl enamides is presented. Electron-rich TangPhos and DuanPhos are found to be effective ligands for Rh-catalyzed hydrogenation of α-aryl enamides and up to 99% ee has been achieved. In contrast, for the hydrogenation of α-alkyl enamide, the Ru-C3-TunePhos complex is more effective and up to 69% ee can be observed. This work is the first report of the hydrogenation of N-phthaloyl enamides.
