Title of article
Chiral bicyclic guanidines: a concise and efficient aziridine-based synthesis
Author/Authors
Ye، نويسنده , , Weiping and Leow، نويسنده , , Dasheng and Goh، نويسنده , , Serena Li Min and Tan، نويسنده , , Chin-Tong and Chian، نويسنده , , Chee-Hoe and Tan، نويسنده , , Choon Hong Tan، نويسنده ,
Issue Information
دوماهنامه با شماره پیاپی سال 2006
Pages
4
From page
1007
To page
1010
Abstract
A series of chiral bicyclic guanidines, either symmetrical or non-symmetrical, was synthesized using a concise and efficient aziridine-based synthetic methodology. Starting from commercial amino alcohols, five synthetic steps were performed, with only three requiring chromatographic purification, giving the desired guanidines in 43–71% overall yield. Preliminary studies using these guanidines showed moderate enantioselectivity for several Michael reactions.
Keywords
Enantioselectivity , Michael reaction , regioselectivity , Guanidine , aziridine
Journal title
Tetrahedron Letters
Serial Year
2006
Journal title
Tetrahedron Letters
Record number
1848774
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