Title of article :
Systemic Immune Response in Whiplash Injury and Ankle Sprain: Elevated IL-6 and IL-10
Author/Authors :
Kivioja، نويسنده , , Jouko and ضzenci، نويسنده , , Volkan and Rinaldi، نويسنده , , Luciano and Kouwenhoven، نويسنده , , Mathilde and Lindgren، نويسنده , , Urban and Link، نويسنده , , Hans، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2001
Pages :
7
From page :
106
To page :
112
Abstract :
Whiplash injury and whiplash-associated disorders (WAD) are significant problems of modern society. Numerous attempts have been made to characterize the nature of whiplash injury. Whether the immune system is involved during the disease process is not known. In a prospective study, using enzyme-linked immunospot (ELISPOT) assays, we examined numbers of blood mononuclear cells (MNC) secreting pro- (IFN-γ, TNF-α, IL-6) and anti-inflammatory (IL-10) cytokines in patients with WAD and, for reference, patients with ankle sprain and multiple sclerosis and healthy subjects. An immune response reflected by elevated numbers of TNF-α- and IL-10-secreting blood MNC was observed in patients with WAD examined within 3 days compared to 14 days after the whiplash injury. The patients with WAD examined within 3 days after the injury had also higher numbers of IL-6 and IL-10 secreting blood MNC compared to healthy subjects. The alterations of cytokine profiles observed in WAD were also observed in patients with ankle sprain when examined within 3 days after trauma. In contrast, there were no differences for cytokine profiles between patients with WAD examined 14 days after the whiplash injury and healthy subjects. Relatively minor trauma like WAD and ankle sprain are associated with a systemic dysregulation in numbers of cells secreting pro- as well as anti-inflammatory cytokines.
Keywords :
cytokines , ELISpot , Whiplash injury , Trauma
Journal title :
Clinical Immunology
Serial Year :
2001
Journal title :
Clinical Immunology
Record number :
1848869
Link To Document :
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