Author/Authors :
Iwasaki، نويسنده , , Junya and Ito، نويسنده , , Hisanaka and Nakamura، نويسنده , , Mitsutake and Iguchi، نويسنده , , Kazuo، نويسنده ,
Abstract :
Enantioselective preparation of the six-membered ring of pachyclavulide B, a briarane-type diterpenoid, was achieved. The key step is desymmetrization of an achiral symmetric substrate by enantiogroup- and diastereoselective epoxidation. The asymmetric epoxidation proceeded with up to 99% de and 94% ee.
