Author/Authors :
Esteban، نويسنده , , Jorge C.S. Costa، نويسنده , , Anna M. and Cruzado، نويسنده , , M. Carmen and Faja، نويسنده , , Montserrat and Garcيa، نويسنده , , Pilar and Vilarrasa، نويسنده , , Jaume، نويسنده ,
Abstract :
Macrolide–nucleoside and macrolide–nucleobase conjugates (chimeras) have been synthesised by linking erythromycin A oxime derivatives and clarithromycin C11,C12-oxazolidinone derivatives with 3′-amino-3′-deoxythymidine or adenine through different spacers; clarithromycin–adenine conjugate 16a is the most active species against Micrococcus luteus.
Keywords :
Clarithromycin–adenine chimeras , Erythromycin–thymidine chimeras , Oxime-linked conjugates , Oxazolidinone-linked conjugates , Macrolide antibiotics
