Author/Authors :
Ball، نويسنده , , Matthew and Bradshaw، نويسنده , , Benjamin J. and Dumeunier، نويسنده , , Raphaël and Gregson، نويسنده , , Thomas J. and MacCormick، نويسنده , , Somhairle and Omori، نويسنده , , Hiroki and Thomas، نويسنده , , Eric J.، نويسنده ,
Abstract :
Preliminary investigations into the synthesis of bryostatins using ring-closing metathesis to form the C(16)–C(17) double bond led to a synthesis of the bryostatin analogue 51; precursors 26 and 52, which possess the geminal dimethyl group at C-18, did not undergo the required ring-closing metathesis.