Author/Authors :
Kuduk، نويسنده , , Scott D. and Marco، نويسنده , , Christina Ng Di and Pitzenberger، نويسنده , , Steven M. and Tsou، نويسنده , , Nancy، نويسنده ,
Abstract :
The addition of Grignard reagents to chiral trifluoromethyl tert-butyl sulfinimine–ethanol adducts affords protected trifluoromethylamines in high yields with good to excellent diastereoselectivities. The stereochemical outcome of the addition is opposite to that expected via a chelation controlled transition state.
