Title of article :
A new and versatile one-pot synthesis of indol-2-ones by a novel Ugi-four-component-Heck reaction
Author/Authors :
Umkehrer، نويسنده , , Michael and Kalinski، نويسنده , , Cédric and Kolb، نويسنده , , Jürgen and Burdack، نويسنده , , Christoph، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2006
Abstract :
A novel one-pot-synthesis of highly substituted indol-2-ones using a combination of Ugi and Heck reaction (U-4CR-Heck) is described. The synthesized indol-2-ones represent an interesting pharmacological scaffold with four potential points of diversity. Thus, this novel reaction-type is amenable to combinatorial high-throughput screening.
Keywords :
Ugi reaction , Heck reaction , one-pot synthesis , Combinatorial chemistry , indol-2-ones , multicomponent reaction
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
